How does Lin28 let-7 control development and disease?

How does Lin28 let-7 control development and disease?

Lin28 is a stem cell pluripotency factor During embryonic development Lin28 levels decline allowing an accumulation of let-7 miRNAs. let-7 induction inhibits the self-renewal of undifferentiated cells and promotes differentiation.

What does let-7 do?

Let-7 miRNAs directly repress a pantheon of well-known oncogenes such as RAS, MYC, HMGA2, BLIMP1, among others (Figures 4, 5; Zhou et al., 2013). In addition, LIN28AB is thought to alter cellular bioenergetics and glucose metabolism that has direct cancer implications.

Is Let-7 a tumor suppressor?

Let-7 targets include genes regulating the cell cycle, cell signaling, and maintenance of differentiation. It is categorized as a tumor suppressor because it reduces cancer aggressiveness, chemoresistance, and radioresistance.

What do you mean by pluripotency?

Definition. Pluripotency describes the ability of a cell to develop into the three primary germ cell layers of the early embryo and therefore into all cells of the adult body, but not extra-embryonic tissues such as the placenta.

What type of RNA is let-7?

let-7 microRNA precursor
RNA type Gene; miRNA
Domain(s) Eukaryota
GO GO:0035195 GO:0035068
SO SO:0001244

Which type of cell is unspecialized?

Stem cells
Stem cells have unspecialized capability and do not have tissue- specific structures to perform specialized functions. They can give rise to specialized cells: Stem cells go through a process called differentiation and create special types of cells (muscle, nerve, skin, etc.).

What are Unipotent stem cells?

e) Unipotent – These stem cells can produce only one cell type but have the property of self- renewal that distinguishes them from non-stem cells. Examples of a unipotent stem cell are a germ line stem cell (producing sperm) and an epidermal stem cell (producing skin).