How long can you live with splenic marginal zone lymphoma?

The median overall survival in most series is about ten years and 70% of the patients can remain treatment free for five years.

What causes splenic marginal zone lymphoma?

The causes of splenic marginal zone lymphoma (SMZL) are mostly unknown. It is sometimes linked to long-term infection with the hepatitis C virus (HCV). But it is important to remember that most people with HCV will not develop lymphoma. SMZL can affect people of all ages, but is most common in people over 70.

How do you treat splenic marginal zone lymphoma?

The most common treatment for splenic MZL is antibody therapy such as rituximab. This is often given on its own for splenic MZL. It can be very effective. You might have an initial course of rituximab to put your lymphoma into remission, followed by maintenance therapy to make your remission last as long as possible.

Is marginal zone lymphoma curable?

Most patients with nodal marginal zone lymphoma present with advanced stage disease and are not likely to achieve cure, even with aggressive chemotherapy regimens. Moreover, there is little evidence that choice of initial therapy has any impact on survival.

What are the symptoms of splenic marginal zone lymphoma?

It usually affects the spleen, bone marrow and blood. It can sometimes affect lymph nodes in the abdomen, but in most cases SMZL doesn’t affect lymph nodes. Inflammation of the liver. Symptoms include jaundice, fever, enlarged liver, abdominal pain and dark urine.

Can you live a long life with SMZL?

Patients with SMZL often have an indolent course with median life expectancy greater than 10 years. However, about a quarter of patients have a more aggressive course, with disease progression and death within the first few years after diagnosis (Arcaini et al, 2006).

What is the prognosis for marginal zone lymphoma?

Five-year survival rates are reported as follows: 88.7 percent for MALT, 79.7 percent for splenic MZL, 76.5 percent for nodal MZL. Though the majority of SMZL run an indolent course similar to EMZL, overall, SMZL has poorer outcomes due to a relatively larger proportion of patients who present with aggressive disease.

What is splenic marginal lymphoma?

Splenic marginal zone lymphoma (SMZL) is a slow-growing (indolent) B-cell non-Hodgkin lymphoma (NHL). It usually affects the spleen, bone marrow and blood. It can sometimes affect lymph nodes in the abdomen, but in most cases SMZL doesn’t affect lymph nodes. SMZL is linked with viral infections, especially. hepatitis.

Can splenic lymphoma be cured?

Splenic MZL is an indolent (slow growing) lymphoma and treatments are used to keep the lymphoma under control, rather than to cure it. There are some good treatments for splenic MZL, and it can be controlled for many years with several courses of treatment.

What does lymphoma, B-cell, Marginal zone mean?

Marginal zone lymphomas are typically slow-growing B-cell lymphomas that comprise 5-10% of lymphoma cases . There are three distinct types, largely based on initial sites of involvement: MALT lymphoma (extranodal marginal zone B-cell lymphoma or mucosa-associated lymphoid tissue lymphoma) This is the most common type of MZL.

What causes lymphoma in the spleen?

Because the spleen is part of the lymph system, this inflammation can cause the spleen to become enlarged. Other potential causes of an enlarged spleen include: malaria. Hodgkin’s disease. leukemia. heart failure. cirrhosis. tumors in the spleen or from other organs that have spread to the spleen.

What is cutaneous marginal zone lymphoma?

Primary cutaneous marginal zone lymphoma is a type of low-grade cutaneous B-cell lymphoma originating from the mucosa -associated lymphoid tissue (MALT). It is a heterogeneous proliferation of marginal zone cells, B cells, small lymphocytes, and plasma cells. Who gets primary cutaneous marginal zone lymphoma?

What are the different types of lymphoma of the spleen?

There are four main types of lymphoma of the spleen: follicular lymphoma, mantle cell lymphoma, splenic marginal zone B-cell lymphoma and lymphoplasmacytic lymphoma. Individuals with follicular lymphoma commonly experience abdominal discomfort.