Is Moxonidine a diuretic?

However, although the drop in blood pressure may explain, in part, the diuretic effect of moxonidine, it may not explain the natriuretic effect, which was not different between SHR and WKY.

What type of drug is moxonidine?

About moxonidine for high blood pressure

What type of drug is chlorpromazine?

Chlorpromazine is in a class of medications called conventional antipsychotics. It works by changing the activity of certain natural substances in the brain and other parts of the body.

Is moxonidine an ACE inhibitor?

Moxonidine is an imidazoline/α-2 receptor agonist used to treat hypertension, especially in cases where ACE inhibitors, β-blockers, calcium channel blockers, and thiazides are not appropriate or provide inadequate blood pressure control.

Is moxonidine a blood thinner?

Key points. Moxonidine is a centrally acting antihypertensive similar to clonidine. Moxonidine may be used as add-on therapy to further lower blood pressure if combination therapy with first- and second-line agents is insufficient or unsuitable.

Is moxonidine bad for kidneys?

Caution is advised in the administration of moxonidine to patients with renal impairment as moxonidine is excreted primarily via the kidney. In these patients careful titration of the dose is recommended, especially at the start of therapy.

Is moxonidine FDA approved?

Moxonidine is an organohalogen compound and a member of pyrimidines. Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension.

What is chlorpromazine hydrochloride used for?

This medication is used to treat certain mental/mood disorders (such as schizophrenia, psychotic disorders, manic phase of bipolar disorder, severe behavioral problems in children). Chlorpromazine helps you to think more clearly, feel less nervous, and take part in everyday life.

Is Clonidine same as moxonidine?

Moxonidine is similar to clonidine, but with reduced adverse effects. As with other centrally acting antihypertensives it will be useful for a small proportion of patients who are resistant or intolerant to first- and second-line drugs.

Can moxonidine cause liver problems?

Rechallenge with moxonidine was considered unethical—given the fact that considerable liver damage had occurred and that effective therapeutic alternatives are available.

How long does moxonidine stay in your system?

The cumulative elimination of unchanged moxonidine via the kidneys is about 50-75%. The mean plasma elimination half life is 2.2-2.3 hours and the renal elimination half-life is 2.6-2.8 hours.

What is a thiazide diuretic?

Thiazide diuretics What are Thiazide diuretics? Thiazide diuretics are a type of diuretic (a drug that increases urine flow). They act directly on the kidneys and promote diuresis (urine flow) by inhibiting the sodium/chloride cotransporter located in the distal convoluted tubule of a nephron (the functional unit of a kidney).

How do thiazides affect the kidneys?

They act directly on the kidneys and promote diuresis (urine flow) by inhibiting the sodium/chloride cotransporter located in the distal convoluted tubule of a nephron (the functional unit of a kidney). Thiazides decrease sodium reabsorption which increases fluid loss in urine, which in turn decreases extracellular fluid and plasma volume.

What is the mechanism of action of hydrochlorothiazide?

Hydrochlorothiazide acts on the distal convoluted tubules and inhibits the sodium chloride co-transporter system. This action leads to a diuretic action and loss of potassium in the urine. The half-life of hydrochlorothiazide varies from 6 to 12 hours.

Can thiazide diuretics cause Lithobid toxicity?

Low levels of potassium and magnesium in the blood can result in abnormal heart rhythms, particularly in those who are also taking digoxin ( Lanoxin) in addition to a thiazide. Thiazide diuretics can increase the risk of lithium (Eskalith, Lithobid) toxicity by reducing the kidney’s ability to eliminate lithium in the urine.