What is familial Hyperchylomicronemia?

Familial chylomicronemia syndrome (FCS) is a rare genetic disorder estimated to affect 1-2 individuals per million. It is a serious disease that prevents the body from breaking down fats consumed through the diet, or triglycerides.

What is familial hypertriglyceridemia?

Familial hypertriglyceridemia is a common disorder passed down through families. It causes a higher-than-normal level of triglycerides (a type of fat) in a person’s blood.

What causes familial Hyperchylomicronemia?

Familial hyperchylomicronemia syndrome is a rare autosomal recessive metabolic disorder caused by the mutation in lipoprotein lipase. It correlates with significant morbidity and distress amongst the patients.

What is cat lipemia?

It’s normal for blood lipid levels to temporarily increase after a meal and return to normal later. This is called lipemia and it can distort blood work results. This explains why your vet recommends that your cat fasts before doing blood tests. There are two types of hyperlipidemia in cats: primary and secondary.

How is Hyperchylomicronemia diagnosed?

FCS is diagnosed based on fasting triglyceride levels above or 750 mg/dL (8.5 mmol/L), which do not respond to standard lipid-lowering therapy (Brahm and Hegele 2015), a history of recurrent abdominal pain and/or pancreatitis, and a family history of high plasma triglyceride levels (Brunzell 1993).

What is the Fredrickson classification?

What is the Frederickson Classification of dyslipidemias?

How common is familial hypertriglyceridemia?

Familial hypertriglyceridemia is a genetic condition that causes the triglyceride levels in the blood to get too high. This relatively common condition affects about 1 in 500 people in the United States.

What does high lipemia index mean?

Conclusion: A markedly elevated lipemia index in a clear serum sample measured on Siemens analyzers Dimension indicates a high possibility for the presence of a paraprotein in the sample.

What is familial Dysbetalipoproteinemia?

Familial dysbetalipoproteinemia is a disorder passed down through families. It causes high amounts of cholesterol and triglycerides in the blood.

What is familial hyperchylomicronemia syndrome?

Familial hyperchylomicronemia syndrome (FCS) is a rare autosomal recessive metabolic disorder caused by mutations in lipoprotein lipase. It presents as elevated triglycerides and chylomicrons in the plasma that can cause an array of symptoms.[1] 

What is familial chylomicronemia syndrome?

Familial chylomicronemia syndrome (FCS) is a rare genetic disorder estimated to affect 1-2 individuals per million. It is a serious disease that prevents the body from breaking down fats consumed through the diet, or triglycerides. These triglycerides are carried in the blood by large structures called chylomicrons.

What is primary hyperlipoproteinaemia in cats?

Primary hyperlipoproteinaemia (hyperchylomicronaemia with slight very low density lipoprotein elevation) is described in two related male cats. Fasting hyperlipaemia, lipaemia retinalis and subcutaneous xanthomas were detected on clinical examination.

What are the treatment options for familial coronary syndrome (FCS)?

There are currently no FDA-approved treatments for FCS. Traditional treatments to reduce lipid levels such as statins, fibrates and niacin are not effective in people with FCS because the effectiveness of these medications depends, at least in part, on a functional lipoprotein lipase enzyme.