What is induced hyperthermia?

Malignant hyperthermia (MH) MH is a life-threatening condition usually triggered by exposure to volatile anaesthetic agents or the depolarising neuromuscular blocker succinylcholine. It affects 1:5000–1:100,000 patients, is reported twice as commonly in males and frequently in young people.

What is MH treatment?

Immediate treatment of malignant hyperthermia includes: Medication. A drug called dantrolene (Dantrium, Ryanodex, Revonto) is used to treat the reaction by stopping the release of calcium into the muscle. Other medications may be given to correct your body’s metabolic imbalance and treat complications. Oxygen.

How do psychostimulants cause hyperthermia?

Clinical reports and animal studies indicate that hyperthermia is a primary effect of psychostimulant drugs and can occur independently of seizures or increased motor activity. Furthermore, activation of particular dopamine receptors in the central nervous system appears to mediate psychostimulant-induced hyperthermia.

Which drugs cause malignant hyperthermia?

According to the Malignant Hyperthermia Association of the United States (MHAUS), the following agents approved for use in the U.S. are known triggers of MH: inhaled general anesthetics, halothane, desflurane, enflurane, ether, isoflurane, sevoflurane, and succinylcholine.

Why would you induce hypothermia?

Therapeutic hypothermia is a type of treatment. It’s sometimes used for people who have a cardiac arrest. Cardiac arrest happens when the heart suddenly stops beating. Once the heart starts beating again, healthcare providers use cooling devices to lower your body temperature for a short time.

What are the symptoms of hyperthermia?

This stage of hyperthermia causes:

• excessive sweating.
• exhaustion.
• flushed or red skin.
• muscle cramps, spasm, and pain.
• headache or mild light-headedness.
• nausea.

What happens if hyperthermia is left untreated?

The athlete is usually lightheaded, experiences chills or shivering and is unable to concentrate. If left untreated, this can progress to heat stroke, which is a severe, acute life-threatening injury that often results in severe brain damage or death.

What is MH illness?

Malignant hyperthermia is a severe reaction to certain drugs used for anesthesia. This severe reaction typically includes a dangerously high body temperature, rigid muscles or spasms, a rapid heart rate, and other symptoms.

How do amphetamines cause hyperthermia?

The dopamine terminal damage and neurodegeneration that occur when amphetamines produce hyperthermia are likely due, in part, directly to hyperthermia increasing ROS, protein misfolding/ dysfunction and altering ion channel permeability in the affected neurons.

What disease is most associated with malignant hyperthermia?

The most common of these conditions are Duchenne and Becker muscular dystrophy. Although rhabdomyolysis with hyperkalemia can be a feature of MH, the MH syndrome usually manifests signs of hypermetabolism, such as respiratory acidosis, metabolic acidosis, and excessive heat production.