What is teratocarcinoma?

Teratocarcinoma is a form of malignant germ cell tumor that occurs in both animals and humans. These tumors comprise an undifferentiated embryonal carcinoma (EC) component and differentiated derivatives that can include all three germ layers.

What does teratoma mean in medical terms?

1. A malignant teratoma, occurring most commonly in the testis in association with embryonal carcinoma. 2. A malignant epithelial tumor arising in a teratoma. A malignant teratoma occurring most commonly in the testis. The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company.

How do teratocarcinomas grow?

Teratocarcinomas are derived from ectopically migrated primordial germ cells,9 and they continuously grow by self-renewal and differentiation of the remaining pluripotent stem cells. Junying Yu, James A. Thomson, in Essentials of Stem Cell Biology (Third Edition), 2014

What is teratoma in mice?

Teratomas and teratocarcinomas are germ cell-derived tumors that occur in the testes and ovaries. They consist of diverse cell and tissue types in various stages of differentiation. Testicular germ cell tumors (TGCT) occur in less than 10% of mice from 129 strains and are rare in other mouse strains.

What are the prognostic implications of teratoma diagnosis?

The prognostic implications of a teratoma diagnosis have been primarily based on three factors: the anatomic location of the tumor, patient demographics, and the presence of coincident malignancy (teratoma with somatic malignant transformation) or immature histological elements.

What is teratocarcinosarcoma (TCS)?

Teratocarcinosarcoma (TCS) is a rare and unusual malignant neoplasm of the sinonasal tract with a heterogenous morphology and an aggressive behavior. Patients are predominantly adults with a male predominance.