What is the role of NFKB in inflammation and cancer?

Nuclear factor-κB (NF-κB) directly and indirectly controls inflammation, cancer cell proliferation and survival, epithelial-to-mesenchymal transition (EMT), invasive behaviour, angiogenesis and metastasis, as well as genetic and epigenetic alterations, cancer stem cell formation, cellular metabolism and therapy …

Does NF kB increase tumorigenesis?

Both of these studies point to a direct role for NF-κB-directed increased intestinal cell proliferation leading ultimately to cancer. A third model of intestinal cancer directly linked the Toll-like receptor (TLR) adaptor protein MyD88 to increased spontaneous tumorigenesis in APCmin mutant mice34.

How does NF kB cause cancer?

Upon NF-κB inhibition, JNK signaling is unleashed leading to excessive oxidative stress and DNA damage (58, 59). This could be one of the mechanisms by which NF-κB acts as a tumor suppressor in both chemically-induced skin cancer and liver cancer.

What does NF kappa B mean?

NF-κB (nuclear factor kappa light chain enhancer of activated B cells) is a family of highly conserved transcription factors that regulate many important cellular behaviours, in particular, inflammatory responses, cellular growth and apoptosis [1][2].

What does the NFKB pathway do?

Nuclear factor kappa B (NF-κB) is an ancient protein transcription factor (Salminen et al., 2008) and considered a regulator of innate immunity (Baltimore, 2009). The NF-κB signaling pathway links pathogenic signals and cellular danger signals thus organizing cellular resistance to invading pathogens.

Is NF kB a tumor suppressor?

NF-κB as a tumor promoter and tumor suppressor. In recent years, in vitro studies have established strong support for the critical role of NF-κB in cancer. Abnormally high NF-κB activity is a clinical hallmark of chronic inflammation and has been found in many types of cancer cells.

Is NF KB inflammatory?

NF-κB is a central mediator of pro-inflammatory gene induction and functions in both innate and adaptive immune cells.

Is NF-kB inflammatory?

Is NF-kB a tumor suppressor?

How does Nfkb cause inflammation?

NF-κB target inflammation not only directly by increasing the production of inflammatory cytokines, chemokines and adhesion molecules, but also regulating the cell proliferation, apoptosis, morphogenesis and differentiation.

What is the role of NF-kappaB in the pathophysiology of cancer?

NF-kappaB activation was shown to provide a critical mechanistic link between inflammation and cancer and is a major factor that controls the ability of both preneoplastic and malignant cells to resist apoptosis-based tumor surveillance mechanisms. NF-kappaB may also be involved in regulation of tumor angiogenesis and invasiveness.

What is nuclear factor kappa B (NF-kB)?

The nuclear factor kappa B (NF-kB) family of transcription factors plays an essential role as stressors in the cellular environment, and controls the expression of important regulatory genes such as immunity, inflammation, death, and cell proliferation. NF-kB protein is located in the cytoplasm, and can be activated by various cellular stimuli.

Why target NF-κB as a cancer therapy?

Given that NF-κB has such an important role in both tumor cells and the tumor microenvironment, targeting NF-κB as a cancer therapy has been explored extensively in the past decades.

Is NF-κB a tumor suppressor?

Upon NF-κB inhibition, JNK signaling is unleashed leading to excessive oxidative stress and DNA damage (58, 59). This could be one of the mechanisms by which NF-κB acts as a tumor suppressor in both chemically-induced skin cancer and liver cancer.