What is Tigar protein?

What is Tigar protein?

TIGAR (TP53 Induced Glycolysis Regulatory Phosphatase) is a Protein Coding gene. Diseases associated with TIGAR include Hypoxia and Hemangioma Of Spleen. Among its related pathways are Direct p53 effectors and DNA Damage.

What is the role of p53 inside of the cell?

Normal Function The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.

Are Tigar Tires good?

Tigar manufactures tyres for cars, vans and 4X4 vehicles, and its brand is one that has become synonymous with high quality at affordable prices. Modern technology used means that the tyres offer drivers a very smooth ride quality and durability that means the tyres are long-lasting and reliable.

Does p53 stop the cell cycle?

Given the importance of p53 as a cellular failsafe mechanism, it is not surprising that its inactivation is a highly selected event in cancer progression. Activated p53 can halt cell division in both the G1 and G2 phases of the cell division cycle.

Where are Tigar Tyres made?

The Serbian tire manufacturer, Tigar Tyres, manufactures tires in its own facility in Serbia. Tigar Tyres is part of the French company Michelin.

Where are Taurus tyres made?

Taurus is a Hungarian tire manufacturer with over a hundred years of tradition. The company produces agricultural tires of good quality and at a good price.

Does p53 bind to DNA?

p53 activates or inhibits transcription by binding to specific DNA target sequences. The tetramerization domain allows oligomerization of this protein, and p53 binds to DNA with highest affinity when it is tetrameric.

How does p53 get activated?

The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20.

Are Tigar tires good?

Are Taurus tyres made by Michelin?

It began its collaboration with tyre giant Michelin in 1996 and has now been developing and producing Taurus tyres alongside its French partner for almost 20 years.