Why is hydroxyurea hazardous?

Why is hydroxyurea hazardous?

Hydroxyurea can cause a severe decrease in the number of blood cells in your bone marrow. This may increase the risk that you will develop a serious infection or bleeding.

Is hydroxyurea a hazardous drug?

Hydroxyurea is an extremely toxic drug with a low therapeutic index. Since hydroxyurea inhibits DNA synthesis, it can result in significant toxicity, including myelosuppression.

Does hydroxyurea increase life expectancy?

CONCLUSION: the survival curve is greater among the users of hydroxyurea. The results indicate the importance of the nurse incorporating therapeutic advances of hydroxyurea in her care actions.

Is there a substitute for hydroxyurea?

Hydroxyurea Alternatives Compared

Hydroxyurea Anagrelide Agrylin anagrelide
Dosage Form(s) Available
Oral capsule Oral capsule Oral capsule
Brand Names
Droxia, Hydrea, Siklos Agrylin N/A

Can you drink alcohol while taking hydroxyurea?

The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of hydroxyurea. you plan to have children, discuss this with your doctor before being treated with hydroxyurea.

How many years can you take hydroxyurea?

Is it safe to take hydroxyurea for many years? Yes. Many people with sickle cell disease have taken hydroxyurea safely for over 20 years. Even young children can take it.

How long can you stay on hydroxyurea?

But, you should try the hydroxyurea for at least six months before stopping It.

Can I take Benadryl with hydroxyurea?

No interactions were found between Benadryl and hydroxyurea.

Is Jakafi better than hydroxyurea?

The researchers concluded that Jakafi provides superior results compared to BAT among patients with PV who have stopped responding to, or are intolerant to hydroxyurea. These results are promising, and provide an effective and well-tolerated treatment option among patients with uncontrolled PV.

Does hydroxyurea affect your teeth?

We concluded that the black discoloration of the teeth associated with hydroxyurea was a rare and unprecedented clinical presentation. Hydroxyurea induced tooth discoloration in the patient. Drug-induced tooth discoloration is categorized into two types: extrinsic and intrinsic.

Can you eat grapefruit while taking hydroxyurea?

Drug and food interactions Do not consume grapefruit or grapefruit juice during treatment with ruxolitinib unless directed otherwise by your doctor.

What is hydroxyurea used for?

Hydroxyurea is an antimetabolite that is used in the treatment of cancer and to stimulate fetal hemoglobin production in sickle cell disease. Hydroxyurea is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, and has been implicated in rare cases of clinically apparent acute liver injury with jaundice.

What is hydroxyurea made of?

Hydroxyurea. Hydroxyurea is a monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle.

What is hydhydroxyurea?

Hydroxyurea is an antimetabolite that is used in the treatment of cancer and to stimulate fetal hemoglobin production in sickle cell disease.

Is hydroxyurea toxic to humans?

Hydroxyurea is a highly toxic drug with a low therapeutic index, and a therapeutic response is not likely to occur without some evidence of toxicity. Hydroxyurea therapy may be complicated by severe, sometimes life-threatening or fatal, adverse effects.